The Daily Dose Year In Review: 2010 Holy Dry, Technical Matter!

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In Ayurvedic practices, turmeric is thought to have many medicinal properties including strengthening the overall energy of the body, relieving gas, dispelling worms, improving digestion, regulating menstruation, dissolving gallstones, and relieving arthritis. Many South Asian countries use it as an antiseptic for cuts, burns, and bruises, and as an antibacterial agent. In Pakistan, it is used as an anti-inflammatory agent, and as a remedy for gastrointestinal discomfort associated with irritable bowel syndrome and other digestive disorders.

In Pakistan and Afghanistan, turmeric is used to cleanse wounds and stimulate their recovery by applying it on a piece of burnt cloth that is placed over a wound. Indians use turmeric, in addition to its Ayurvedic applications, to purify blood and remedy skin conditions. Turmeric paste is used by women in some parts of India to remove superfluous hair. Turmeric paste is applied to the skin of the bride and groom before marriage in some parts of India, Bangladesh, and Pakistan, where it is believed to make the skin glow and keep harmful bacteria away from the body. Turmeric is currently used in the formulation of several sunscreens.

Several multinational companies are involved in making face creams based on turmeric. In Ayurvedic medicine, turmeric is a well-documented treatment for various respiratory conditions e. In traditional Chinese medicine, it is used to treat diseases associated with abdominal pain Aggarwal, Ichikawa, and Garodia From ancient times, as prescribed by Ayurveda, turmeric has been used to treat sprains and swelling Araujo and Leon In both Ayurvedic and traditional Chinese medicine, turmeric is considered a bitter digestive and a carminative. Unani practitioners also use turmeric to expel phlegm or kapha , as well as to open blood vessels in order to improve blood circulation.

It can be incorporated into foods, including rice and bean dishes, to improve digestion and reduce gas and bloating. Sometimes, turmeric mixed with milk or water is taken to treat intestinal disorders as well as colds and sore throats. Although modern medicine has been routinely used in treatment of various diseases, it is less than years old.

Traditional medicine, in comparison, has served mankind for thousands of years, is quite safe and effective. The mechanism or the scientific basis of traditional medicine, however, is less well understood. Throughout the Orient, turmeric is traditionally used for both prevention and therapy of diseases.

Modern in vitro studies reveal that turmeric is a potent antioxidant, anti-inflammatory, antimutagenic, antimicrobial, and anticancer agent Table Turmeric, used in cooking and in home remedies, has significant antioxidant abilities at different levels of action. Studies indicate that sufficient levels of turmeric may be consumed from curries in vivo to ensure adequate antioxidant protection. As an antioxidant, turmeric extracts can scavenge free radicals, increase antioxidant enzymes, and inhibit lipid peroxidation.

Turmeric extracts were found to inhibit microsomal activation-dependent mutagenicity of 2-acetamidofluorene Soudamini et al. Numerous lines of evidence suggest that turmeric exhibits anti-inflammatory activity. A combination of several fractions that contained the turmeric oils was more effective than curcuminoids in inhibiting PGE2 production Lantz et al. A hydroethanolic extract of turmeric was recently found to inhibit activation of human dendritic cells in response to inflammatory cytokines Krasovsky et al.

Besides these properties, turmeric has strong antimicrobial properties. Turmeric was also found to inhibit histamine production in Morganella morganii potent histamine-producing bacteria. However, inhibition of histamine production and histidine decarboxylase activity of turmeric is less than that of clove and cinnamon Shakila, Vasundhara, and Rao Turmeric extract was found to inhibit growth of the foodborne pathogen V. A methanolic extract of turmeric inhibited the growth of different strains of Helicobacter pylori with a minimum inhibitory concentration range of 6.

Among the various plant extracts that killed H. Ethanolic extracts of C. Tests using the agar disc diffusion method for detecting antifungal activity showed that a crude ethanolic extract of turmeric killed all 29 tested clinical strains of dermatophytes. This extract exhibited an inhibition zone range of 6. The anticancer activities of turmeric include inhibiting cell proliferation and inducing apoptosis of cancer cells.

Ar-turmerone, which is isolated from turmeric, induced apoptosis in human leukemia Molt 4B and HL cells by fragmenting DNA to oligonucleosome-sized fragments, a known step in the process of apoptosis Aratanechemuge et al. Moreover, the nucleosomal DNA fragmentation induced by ar-turmerone was associated with induction of Bax and p53 proteins, rather than B cell lymphoma 2 Bcl-2 and p21, and activation of mitochondrial cytochrome c and caspase-3 Lee This study showed that turmeric extract repressed the production and secretion of hepatitis B surface antigen from HepG 2.

Both the preventive and therapeutic effects of turmeric have been examined in animal models Table These studies report that this yellow spice exhibits anticancer Azuine and Bhide ; Deshpande, Ingle, and Maru ; Garg, Ingle, and Maru , hepatoprotective Miyakoshi et al. It prevents carcinogenesis at various steps, including inhibiting mutation Polasa et al. The mechanisms of anticarcinogenesis were mediated through inhibition of DMBA-induced expression of the ras oncogene product, induction of p21 and its downstream targets, mitogen-activated protein kinases, and reduction of proliferating cell nuclear antigen and Bcl-2 expression.

Inhibition of tumor growth in mice by turmeric extracts in a dose-dependent manner. Dietary turmeric inhibited ethyl acetoxymethyl nitrosamine-induced oral carcinogenesis in Syrian hamsters. However, the inhibitory effect of a combination of turmeric and betel leaf extract was found to be higher than that of the individual constituents Azuine and Bhide a. Moreover, the incidence and multiplicity of BaP-induced forestomach tumors in female Swiss mice were significantly inhibited by turmeric extract Azuine, Kayal, and Bhide Chandra Mohan, Abraham, and Nagini also showed that pretreatment with turmeric alone and in combination with tomato and garlic extract significantly lowered the frequencies of DMBA-induced bone marrow micronuclei, as well as the extent of lipid peroxidation.

They revealed that these changes may be mediated by the antioxidant-enhancing effects of the dietary agents. Combined treatment of urethane, a well-known mutagen, and turmeric displayed an inhibition of the genotoxic effect of urethane by turmeric el Hamss et al. Decrease in tumorigenesis caused by turmeric is also associated with inhibition of DNA adduct formation.

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Inclusion of turmeric at 0. BaP injection Mukundan et al. Irrespective of whether turmeric was included in the diet or applied locally, it significantly decreased DMBA-induced DNA adducts at the target site and consequently lowered the number of tumors and tumor burden in the studied animals Krishnaswamy et al. Turmeric contains several substances capable of inhibiting chemical carcinogenesis.

It enhanced the xenobiotic-metabolizing enzymes in the hepatic tissue of rats fed with 0. Detoxifying enzymes such as uridine diphosphate UDP , glucuronyl transferase, and glutathione-S-transferase significantly increased in turmeric-fed mice as compared with control animals Goud, Polasa, and Krishnaswamy Ethanolic turmeric extract was found to have opposing actions on murine lymphocytes and on Ehlrich ascitic carcinoma cells. Turmeric enhances lymphocyte viability and blastogenesis, but induces formation of cytoplasmic blebs and plasma membrane disintegration of tumor cells.

Thus, it is suggested that turmeric is a conducive agent for lymphocytes and inhibitory as well as apoptosisinducing for tumor cells Chakravarty and Yasmin A comparative study of edible plants like C. Thus, edible plants that show in vivo antitumor activities may be recommended as safe sources of antitumor compounds Amara, El-Masry, and Bogdady Turmeric showed antioxidant potential by lowering oxidative stress in animals.

A study showed that a diet containing 0. A study conducted on mice showed that turmeric extract inhibited membrane phospholipid peroxidation and increased liver lipid metabolism, which indicates turmeric extract has the ability to prevent the deposition of triacylglycerols in the liver. Oral administration of a nutritional dose of turmeric extract decreased susceptibility to oxidation of erythrocyte and liver microsome membranes in vitro.

When turmeric hydroalcoholic extract 1. Levels of hydroperoxides and thiobarbituric acid-reactive substances in liver microsomes were also low Mesa et al. Turmeric also seems beneficial in preventing diabetes-induced oxidative stress. In diabetic rats, an AIN93 diet containing 0. This diet also inhibited expression of vascular endothelial growth factor in diabetic rats Mrudula et al. Further, it suppressed increase in blood glucose level in type 2 diabetic KK-Ay mice.

A dose of 0. Further, turmeric appeared to minimize osmotic stress. Most importantly, aggregation and insolubilization of lens proteins due to hyperglycemia was prevented by turmeric, indicating that it prevents or delays the development of cataracts Suryanarayana et al. Turmeric has been reported to be hepatoprotective. Diets containing turmeric extract suppressed increases in lactate dehydrogenase LDH , alanine aminotransferase ALT , and aspartate aminotransferase AST levels caused by D-galactosamine-induced liver injury in rats Miyakoshi et al.

Turmeric is also effective against neuronal, cardiac, and kidney disorders. The effect of turmeric on myocardial apoptosis and cardiac function was examined in an ischemia and reperfusion model of myocardial injury.

Turmeric is also useful against depression Yu, Kong, and Chen ; Xia et al. Its ethanolic extract markedly attenuated swim stress—induced decreases in serotonin, 5-hydroxyindoleacetic acid, and noradrenaline and dopamine concentrations, as well as increases in serotonin turnover. Also, this extract significantly reversed swim stress—induced increases in serum corticotropin-releasing factor and cortisol levels and thus regulated neurochemical and neuroendocrine systems in mice Xia et al.

These results demonstrate that turmeric has specific antidepressant effects in vivo. However, since curcumin is not water soluble, the agent in aqueous extracts of turmeric responsible for this activity is not clear. The antiarthritic effects of turmeric include inhibition of joint inflammation and periarticular joint destruction.

It also inhibited inflammatory cell influx, joint levels of PGE2, and periarticular osteoclast formation in rats Funk et al. Turmeric was found to be effective against carrageenan-induced edema in rats Yegnanarayan, Saraf, and Balwani , and water extracts of turmeric were more active than alcohol extracts in the inhibition of carrageenan-induced edema. Turmeric extract, when given intraperitoneally, was found to be more active than hydrocortisone Ghatak and Basu The yellow powder of turmeric is known to have potent vasorelaxant activity and to decrease the atherogenic properties of cholesterol.

A study showed that supplementation of turmeric in the diet controlled arterial blood pressure in animals and enhanced vasorelaxant responses to adenosine, acetylcholine, and isoproterenol Zahid Ashraf, Hussain, and Fahim Another interesting property of turmeric is its wound-healing ability.

Gujral, Chowdhury, and Saxena found that turmeric has the property of healing wounds and ulcers in rats and rabbits. Other studies in rabbits revealed that stimulation of mucin secretion could protect the stomach from ulcer Mukerji, Zaidi, and Singh Besides causing these effects, addition of turmeric to the diet significantly improved weight gain of broiler chicks and reduced their relative liver weight.

Turmeric also ameliorated the adverse effects of aflatoxin on some serum chemistry parameters total protein, albumin, cholesterol, calcium in broiler chicks and restored antioxidant functions in terms of level of peroxides, superoxide dismutase activity, and total antioxidant concentration in their livers Gowda et al. Turmeric acts as a digestive stimulant. As a dietary supplement, it favorably enhanced the activities of pancreatic lipase, chymotrypsin, and amylase. Moreover, turmeric mixed with other spices such as coriander, red chili, black pepper, and cumin brought about a pronounced stimulation of bile flow and bile acid secretion Platel et al.

Mukerji, Zaidi, and Singh showed that turmeric increases the mucin content of gastric juice in rabbits. Studies conducted by Farnsworth and Bunyapraphatsara , Supniewski and Hano , and Prucksunand et al. After eating turmeric, secretion of gastrin hormone from the antrum of the stomach may be inhibited. Turmeric may possess local membrane-anesthetizing activity at the antrum of the stomach, which then inhibits secretion of gastrin in the same way as oxethazaine, the active ingredient of strocain Masuda This is the reason turmeric is administered before meals.

Turmeric has been tested against various diseases in humans Table In one study, the antimutagenic effects of turmeric were examined in 16 chronic smokers Polasa et al. Turmeric was given in doses of 1. In six nonsmokers, on the other hand, no change in urinary excretion of mutagens was noted. These results suggest that dietary turmeric is an effective antimutagen and may be useful in chemoprevention. In another study, the effect of turmeric was examined on patients with irritable bowel syndrome. Alcoholic extract of turmeric offered protection against BaP-induced increase in micronuclei in circulating lymphocytes of healthy individuals Hastak et al.

The number of micronuclei from oral exfoliated cells of OSF patients before and after treatment with turmeric extract was recorded. They found that the number of micronuclei in oral exfoliated cells decreased substantially and was comparable with that of normal, healthy individuals Figure Inhibition of micronuclei formation in oral submucous fibrosis OSF patients: Turmeric was also found useful in healing peptic ulcers. In a phase II clinical trial, 45 patients with peptic ulcer received capsule-filled turmeric orally in the dose of 2 capsules mg each five times daily. A double-blind trial found turmeric to be helpful for people with indigestion and for people with stomach or intestinal ulcers, but it was shown to be less effective than antacids Kositchaiwat, Kositchaiwat, and Havanondha An ethanol extract of turmeric was found to produce remarkable symptomatic relief in patients with external cancerous lesions.

A study on eight healthy subjects showed that the presence of turmeric in curry increases bowel motility and activates hydrogen-producing bacterial flora in the colon, thereby increasing the concentration of breath hydrogen Shimouchi et al. Turmeric paste is used to heal wounds or to protect against infection. In certain parts of Bangladesh, turmeric is the most common application on the cut umbilical cord after delivery Alam et al.

Turmeric has medicinal properties due to its bioactive components. One of the important components of turmeric is its volatile oil. The role of turmeric oil in in vitro animals and in human is shown in Table Turmeric oil inhibits Trichophyton-induced dermatophytosis in guinea pigs. Apisariyakul, Vanittanakom, and Buddhasukh showed that 15 different isolates of dermatophytes are inhibited by turmeric oil at dilutions of 1: Interestingly, none of the dermatophyte isolates was inhibited by curcumin.

Studies of the antiviral effects of the zedoary turmeric oil spray in the respiratory tract showed that whereas influenza virus, parainfluenza viruses I and III, respiratory syncytial virus, and adenoviruses 3 and 7 were inhibited slightly, parainfluenza virus II was significantly inhibited by this turmeric compound Huang et al.

Curcuma oil ameliorated the ischemia-induced neurological functional deficits and the infarct and edema volumes in rats. It downregulated inducible nitric oxide NO synthase iNOS -derived NO produced during ischemic injury, which coincided with an increased survival rate of neurons Dohare et al. The neuroprotective activity of curcuma oil against cerebral ischemia is associated with its antioxidant activities.

Further, cucurma oil attenuated delayed neuronal death via a caspase-dependent pathway. Thus, curcuma oil appears to be a promising agent for the treatment of not only cerebral stroke but also other disorders associated with oxidative stress Rathore et al. A study revealed that ingestion of turmeric oleoresin and essential oil inhibits the development of increased blood glucose and abdominal fat mass in obese, diabetic rats Honda et al.

Turmeric volatile oil is effective against disorders of the respiratory tract. The volatile oil is active in removing sputum, relieving cough, and preventing asthma. Thus, turmeric volatile oil may be an efficacious drug in the treatment of respiratory diseases Li et al. This oil acts as a repellent against both day- and night-biting mosquitoes Tawatsin et al. Hexane extracts of C.

The use of turmeric as a spice and as a household remedy has been known to be safe for centuries. To date, no studies in either animals or humans have discovered any toxic effects associated with the use of turmeric Lao et al. Food and Drug Administration FDA has conducted its own clinical trials with turmeric and published a page monograph. Thus, in the United States, turmeric and its components are currently being used in mustard, cereals, chips, cheese, butter, and other products http: In a phase I clinical study on the safety and tolerance of turmeric oil use, the oil was administered orally to healthy volunteers for 3 months.

No side effects of turmeric oil intake were observed in 3 months on body weight, blood pressure, and hematological, renal, or hepatic toxicity Joshi et al. The beneficial effects of turmeric are traditionally achieved through dietary consumption, even at low levels, over long periods of time.

A precise understanding of effective dose, safety, and mechanism of action is required for the rational use of turmeric in the treatment of human diseases. Further clinical studies are warranted if turmeric is to be employed in meeting human needs and improving human welfare. The activities of turmeric include antibacterial, antiviral, anti-inflammatory, antitumor, antioxidant, antiseptic, cardioprotective, hepatoprotective, nephroprotective, radioprotective, and digestive activities. Phytochemical analysis of turmeric has revealed a large number of compounds, including curcumin, volatile oil, and curcuminoids, which have been found to have potent pharmacological properties.

Turn recording back on. National Center for Biotechnology Information , U. I n V itro S tudies with T urmeric Throughout the Orient, turmeric is traditionally used for both prevention and therapy of diseases. I n V ivo S tudies with T urmeric Both the preventive and therapeutic effects of turmeric have been examined in animal models Table C linical S tudies U sing T urmeric Turmeric has been tested against various diseases in humans Table B, Ichikawa H, Garodia P.

From traditional Ayurvedic medicine to modern medicine: Identification of therapeutic targets for suppression of inflammation and cancer. Expert Opin Ther Targets. I did it hoping to help save another pet for not going through what Ella suffered for. Thanks for the info, I can feel your pain. On Friday December 7 , my dog went to the vet as she had sore ears and she hurt her paw so the vet put Shelby our sheltie on dermaxx one half for five days I gave her the one half on Friday night and not to long after she was not herself on Saturday morning I gave her another one and again after the pill she was not herself she started panting more than she does and would not eat so I sad to my husband im not going to give her those pills any more all sunday she had the poos all night and the smell would make you sick so I gave her machine that I had hear from Doctor Goodpet for the poos and in the morning gave her a little food as she wanted to eat here hoping that she comes back if I had not read the reviews on line I may not of had my Shelby this morning.

My vet, whom I have trusted implicitly over the years, put him on Deramaxx. After months of being on it, and me stupidly not putting two and two together with gradual loss of appetite and increased drinking and urination, I finally took him in and his renal and liver functions are elevated.

So the damage is done…whether or not he will level out now that he is off of it remains to be seen.

Did he offer any suggestions for trying to reverse the damage? A previous commenter here Chet used milk thistle to help her dog who had liver problems from Deramaxx. Here is a link with info: I hope and pray your dog makes a full recovery! Thank you for sharing his story here. And thank you for your kind words.

I have done some Pro Se litigating and have won. It is not all that hard to be a lawyer. Like doctors, lawyers try to hide information and computer filings from the public. Both doctors and lawyers use a dead language called Latin to try and confuse you and make you think you need them. I have lost three dogs to that deadly N. You definitely need to get other opinions from other vets. I am betting in every case the answer is yes. Ask them if there is blood work involved and how often.

The answers you will receive should make up your mind on your next move. Always look up any drug any one you love takes to find out the side effects and only trust yourself and close family.

Deramaxx Killed My Best Friend « Amy Writes

Please remember, if you let people get away with hurting your best friend, they will continue to hurt others. Please write Amy to thank her for financing this site as she is doing a great deed by exposing the poisons that are given to people and pets I am very sorry that you had to join this club. We must all try to spread the word and maybe save others from this heartache.. Rimadyl killed my sheltie which is in the same class as Dermaxx. He vomited blood for days before his death.

Vet would not believe that Rimadyl was the cause. This vet did nothing to help him.

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In any event people need to know what these anti-inflammatories do to our dogs. They took the shit off of the market for humans due to serious side effects and then gave it to the vets for our animals. All comes down to Big Pharma continuing to poison us and making money at doing it. Did you know that Coumadin, a blood thinner is actually arsenic. Did you know that you can safely take vitamin E and have the same blood thinning effects that you are trying to get with taking Coumadin?

Ask for safer alternatives. Carol, thank you for your bold statements and for sharing your story and experience. Thank you for adding your voice. My sympathies for the loss of your dog. Have you thought of using one of the petition generating websites to gain public support in this matter?

Here are the websites: You can look around a bit on these sites to see how other people have approached it. If you decide to start one, please post a link here so all those who have commented can sign it. Lisa, thank you for this. Amy, I just came across your post when I was researching hypothyroidism in dogs. My heart goes out to you on the loss of your beloved Holly! I have tears for you and know how much our dogs mean to us! They are our family,our babies, and we will do everything to help them when they are not acting just right!

Tara, our 12 year old Bearded Collie was just diagnosed with hypothyroidism and I am concerned with the dosage that she is on…I have thypothyroidism and she is on a much stronger dose than I am on. I know that she is a dog and there is a difference in drugs but I am trying to learn as much as I can to make sure that she is getting the right treatment,etc. We go back to her vet in a month to recheck her blood count,T4 to make sure that her cholesterol has gone down and she is on the right dosage. She is on Thyro Vet, 0. I hope that the love that you had for Holly has doubled for Hannah.

Again,I am so sorry that you had to lose Holly in such a tragic way and that everyone who sees your post will follow their gut and question the drugs that their animals are given the same way that they question their own Doctors! I really appreciate your kind comments. Unfortunately, we recently lost Hannah to what appears to have been a pancreatic tumor. Hopefully the dosage of her medication is correct and helping. Thank you for reaching out. Amy, I am so pleased that you have posted warnings about Deramaxx, unfortunately we read them too late. Our beloved 9 yr old yellow lab, Bert, went in for routine knee surgery, was very healthy, and his blood work was perfect.

He even came home healthy and was doing extremely well… Then he stopped eating…Bertie never turned down food. After numerous calls to the vet we even tried sweet potatoes and baby food. Like you my husband and I are kicking ourselves for continuing to give him that poison…Deramaxx. I swear he was trying to tell us with his eyes that it was killing him. He refused to take it that last day. Btw my vet claimed no way it was the Deramaxx, well then tell me ,what the hell made a healthy dog die in my arms????

It breaks my heart that you are going through this. My vet said the same thing, too, when I told him I thought it was the Deramaxx making Holly sick. From what I understand, the result of the class action lawsuit against Novartis was language being added to the drug literature telling vets to do proper monitoring while the dog is on the med, and to provide a stomach-coating med with it to avoid the ulcerating effects of the drug. Thank you for sharing your story here, though.

Holy Basil

It does help others. This post gets hundreds of hits every day. So people are reading and learning about the dangers of this medication. Wishing you healing and peace. My cat of just a year has been on deramex he had a 5 day cause of it as he had a limp in his back leg but the last couple of days he been off his food and has been hiding under my bed still limps and I rang vets tonight to say I was concerned and I have to take him back in morning but I am telling him strait that he is not having any more deramex and I want him sorted.

I am working myself silly now I am going to loose him he is only a baby still. I have a severly ill Cavalier who just got out of the hospital after 5 days because the vet gave him 6 days of this poison. We started our dog on Deramaxx on Friday July 3. We said goodbye to him yesterday only 6 days after starting Deramaxx. Granted, he was 12 and had his share of health problems over the years previously had two types of cancer, cushings disease, blindness from SARDS , but I do believe the Deramaxx led to his accelerated death.

He was stable with his other ailments no signs of cancer for a couple of years and regularly had checkups and vet visits as recently as the last couple of weeks. On Monday I noticed he was bleeding from his face. On Tuesday, we went for our nightly walk and he was moving much slower than normal. When we got home he was circling and restless. He then opened his mouth and it was bleeding. We brought him to the ER and they said it was likely low platelets causing ITP and they admitted him, saying he likely would recover.

Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition.

He was stable on Wednesday morning. They did chest X-rays and an ultrasound and they were clear. By Wednesday evening we were told he significantly declined. His mouth was bleeding profusely and his stomach was all bruised, and he was showing signs of bleeding in the brain that was causing neurological issues. We put him down on Thursday. Is there any way to fight back against Novartis? He was our whole life and our home and hearts are completely empty now. Tuesday morning, July 28th, our beautiful Rottweiler, Kasey, became another Deramaxx death statistic!

I feel your pain…like October was yesterday. Maybe this will help ease the pain: Be well and cry often. My loving friend also died on Deramaxx, just last Friday. The one thing I do not understand is the vet does blood work every 6 mons. Why did they NOT see the liver damage.

Not sure who to blame. My heart is broken. Do I still go to that vet? I have 2 new puppies. It seems like 6 months may have been too long to go between checks for liver function. After Holly died, there was no way I could go back to that vet. I still struggle the times I have to drive past the clinic. We found a new vet, and met with him first to explain where we were coming from.

I hate that it continues to happen. Derrmaxx killed my Big Boy tonight. I wrote the summary below last night to post on Facebook because Zeus has been buddies with many of my friends and I wanted to keep them updated. So we told him good bye and buried him on the back of our property. Ive had a lot of people asking about our Zeus but have been too busy to write it all down but here is the long but summarized story.

I took him to the ER vet that night but he perked back up and after speaking to one of the techs I brought him home. The ER vet looked him over and gave him food which of course he had to prove momma wrong and eat. He said the best course is to let his vet keep working with him since she had the history and could do the follow up. So I took him home, he had eaten and that made me feel a little better.

At this point he had hardly moved from whatever spot he found when we brought him through the door from the trips back and forth. He would not get up to go outside unless he was lifted up and forced and on multiple occasions would lay there and pee himself. She decided to keep him overnight for possibly a couple nights and see if she could get his health up. She called mid day. The test came back good but he was severely dehydrated, IV fluids and keep watching was the plan. She called back a couple hours later.

She had noticed him having trouble breathing so she redid the test and took an Xray. His stomach was full of fluid. She asked if she could die test to check his bladder. She had us come get him and transfer him to the ER vet so he would have a full staff to watch over him after the surgery.

They found a hole where his stomach and intestine attach which caused him to get the fluid in his stomach thus causing peritonitis inflammation and infection of the inside of the entire abdominal cavity. The vet said the infection has weakened his entire intestine as well as the other organs within the stomach. They were able to repair the section where the hole was located however because of how weak his internal tissue is there is no guarantee the repair will last.

We got him from the ER vet at 7: He has to be continually watched by doctors ready to reopen him at anytime and if he is reopened his chances of survival go down even more. So when his vet closed at 6 we took him back to the ER vet for the night and at 7: His incision now is close to 2 feet as it is the entire length of his stomach. This all started as a standard neuter and Deramaxx for post op pain medication but instead Deramaxx almost killed our big boy.

Amanda, I am so, so sorry! What a horrific ordeal for Zeus and your family to go through. But you and the other grieving owners on this thread are in my prayers. I hate that this continues to happen. Thank you for sharing your story here. Maybe it will help keep it from happening to someone else. My very healthy and wonderful dog had ruptured a disc two years ago and had permanent damage to some of the nerves of her rear end.

She was able to walk but was wobbly, as her back legs were weak. She responded well to acupuncture for a long time, but eventually the acupuncture had done as much as it could. I chose to have her engage in physical and hydro therapy. The vet at the clinic where she received this treatment put her on Deramaxx to control any inflammation due to arthritis in her hips. It was a horrible experience to go through and my heart is broken. At bedtime, she was fine and 2: Not understanding the seriousness of what was happening with my dog, I decided to keep her home until the prescribing vet could see her in the morning.

She was dead 10 hours later. The vet who saw her that day said that absolutely nothing could have been done to change the course of what happened. I am absolutely, firmly convinced that the Deramaxx killed her. It should never have been prescribed for her anyway, given the meds she was already taking.

I phoned the company and provided all the info I had concerning what happened. The company is obligated by law to report this to the FDA, and the company vet I talked with said he would be doing that. Nothing can fill the incredible void that her unnecessary death has left me with. Keller, your story is so similar to ours with Holly. Words are little help in the face of such heartache, I know. Thank you for sharing your story here and for reporting it to the company. My heart goes out to you. I would like to know if you think we might have had a chance to save her if we had taken her to the emergency vet clinic when her first symptoms began.

The vet who saw her in the morning said that she had something that happened to her brain stem and that was what killed her. I wish I had found this blog before all this had happened as, if nothing else, I would have requested a necropsy.

I have so many unanswered questions. One commenter here by the name of Chet saved her dog, but it was a very slow process. Some dogs are affected very quickly, some dying after a single dose. The drug does affect neural function Holly was very wobbly, as if drunk. It sounds your dog was severely impacted this way if the vet noticed. I hate that this still happens.

Monday is the anniversary of losing Holly. Five years later it still tears me apart. Amy, I currently have my Grt Dane on Duramaxx. Before I read your and other stories I noticed a change in his behavior. He has arthritis, so perhaps the Tramadol will help. He gets pepcid before his meals.

Thank you and all the others who posted the stories. My heart goes out to all of you for your loss. Thanks for your comment. You should ask your vet to check his liver and kidney numbers to see if heMs showing any toxicity. And I hope your vet listens to your concerns. Some dogs to well on the medicine, but others done. Wishing your dog good health and no ill effects from this drug. Julia, you might want to ask your vet for gabapentin Neurontin , which my dog was on and so am I.

It also has no negative interactions with any of the other drugs I take to make my quality of life better. The more I learn, the more I am firmly, totally convinced that Deramaxx killed my beautiful dog and no one will ever make me change my mind. Thank you for sharing that info about gabapentin, Keller. I wish everyone whose dog was very ill or died would make it a practice to report it to the company that makes Deramaxx and also to the FDA.

I have lived in this world for a long time 67 years and I am seeing more potent drugs hit the market. The worst seem to be Non-steriodial, anti inflamatory drugs, or N. S, of which Derramaxx is one of them. They are very profitable to the vet and keep the Gov. It is up to you to read up on the safety and in certain breeds Derramaxx can be good or a poison.

It is the age we now live in. Sorry for the spelling but my computer has been hacked and I need to notify a lot of people. Lily, our year-old, lb bichon, started limping 6 weeks ago. In retrospect, we think she pulled something trying to jump onto the couch. But the symptoms were similar to the luxating patella our previous bichon had 19 years ago, which required surgery to fix.

I administered daily, and we kept her from exercising vigorously. I have no doubt that deramaxx has caused adverse effects. But it does have beneficial effects when used cautiously, and in this case, it spared Lily from surgery — from which she might not have recovered. Unfortunately, though, for many of us we found out the hard way and too late that it can also be poison. Wishing your dog continued health. Our 11 year old lab, Mae, was in pretty good health when she began to develop some minor arthritis. She was prescribed Deramaxx which seemed like a miracle drug at first- energy!

We had them removed, but within a week, she suddenly became gravely ill, in a matter of hours. She was rushed to emergency,and when our vet said she had no fever, etc. She died suddenly the next morning from internal bleeding, possibly from a ruptured gallbladder. When he called me, he sounded despondent and mentioned the Deramaxx. It seems like a small thing, but it will help others. I am saddened by each of the unfortunate experiences shared as a result of the negative reaction to Deramaxx.

A common element of the responses leads to a breed specific reaction in many of the postings. Collie breeds are clearly represented. Demarex was prescribed to assist her post operative pain and inflamation reduction. Joie was 11 at the time of the amputation, and she remains vital, vigorous for her age now close to 14 years. I appreciate that there are adverse events due to medication. But there are many successes as well.

I am sorry for your loss, painful and distressing. Hanging onto the negativity will not benefit you or her memory. Each animal we take into our lives enriches us. They have their lifespan, it does not match ours. I have learned to take each animal I take on as a gift, enjoy their life, do the best I can to keep them healthy, mourn their passing, and celebrate the gift given.

How many dead dogs is too many? The drug helped your dog, so all others be damned? Do you realize this exact same thing happened with people? The drug was called Vioxx and it killed many. The FDA took the drug off the market when it was made clear it was dangerous. It caused the exact same damage as Deramaxx. It is the same drug. Well, except for yours. Given your logic, was it ok for people to die from Vioxx because it saved one? How many people dying is too many? Do you see how your argument falls apart?

Try empathy for a change. I am tired of having to justify my anger over my dog being killed by this drug. I am tired of being told to move on, when my intention here is to help others. And I am tired of the profit-driven FDA that puts their greed ahead of patient safety. To watch your dog die a horrible death because of something you did is something I wish on no one. I can almost bet that not one person here was told that this drug could possibly kill their dog. I was just handed this medicine and sent on my way. When you lose a dog in this way it is something you never get over.

I know that Anthony and others who have said similar things means well, but I have to agree with you, Janet and Amy. To lose a vigorous and healthy dog in such a horrific manner is not something that we will ever forget. I felt lost and relived that terrible trauma for a month. I, too was told nothing about this drug other than that she needed it to help with inflammation from her arthritis.

Not right and and not acceptable. Sorry for the loss of all the canines here. All of my Dogs have had Deramax, none have died from it. I have had 4 Labs and a Pyrenees. One was killed by the complications of being hit by an unkown careless driver after she escaped her fence. A truck driver found her and she survived to live 6 more years with the help of Deramax for pain and then Morphine. One was killed by a snake and one by a blood disorder.

I would say it has to do more with the dogs genetic predisposition than the medicine. I trully thank this family that lost Their pretty female baby Holly. To the horrible medicine Deramaxx. My God I cant tell you how much it hurt me as I was reading your message to us dog owners I have a little girl 2 year old terrier and tge same thing happened to my baby hurt her left back Leigh playing. Her last doctor told me tgat if she didnt get better that we could do some therapy better.

And my deepest condolence. About your little girl Holly.

Amy Writes

And I thank you very very much for opening my eyes. Thank you for your kind words. Wishing her a full recovery and a long, happy life. We loose someone like your Holly. You may not be aware but Deramax is discontinued now and for reasons simular to causing complications to other pet patients like Holly.

From what I understand there was a delay in production a couple of years ago, but it appears to still be on the market and available, at least in the US. If someone has current information showing otherwise, please share. Deramaxx was just prescribed to our Dog McGee two weeks ago. We have moved and had to take him to a new vet I was very hesitant to start him on it as he is a fairly healthy 13 year old lab, just has slowed down. I wish I would have read about the drug before I gave it to him, I would have never given it to him.

I would get him to an emergency clinic right away. Pepcid and milk thistle can help. The vet may not believe you. It may be helpful to take along this blog or other stories as evidence. I will pray for McGee. Robyn, please take McGee to an emergency vet right away. Take this blog along and other stories as evidence if needed. Pepcid and milk thistle can help protect his digestive system and liver. If possible please let me know what happens. I have been given deramaxx for my 10 year old Rottweiler for her hips. Thank you for your article. Thank you and I am sorry for your loss.. Lots of love ps never ever buy Walmart meats boycot them their chicken wings were making me ill for a year till I figured out it was the wing meat was bad even if cooked well also a guy online has a video on YouTube of worms in the pork ribs if your reading this refer to my above info if your dog has had any symptoms like holly also anyonefeeding table scraps MUST read my above post SN with love.

Thank you I am now aware of that drug. Deramaxx killed our beloved Rottweiler, Marley, in just 3 out of 14 doses. His intestines were ulcerated beyond repair causing him to become septic. It was 6 years ago today actually. We trusted our vet. I wish I had done more research before giving him the medication but never did I think our vet would do such a wreckless thing.

Yesterday afternoon September 19, I took my 1 year old German Shepherd to the vet, because he was limping and the vet prescribed Deramaxx. I have been taking my pets to this Veterinarian for 15 years, so I really thought nothing about giving my dog this medication, so when we got home I gave him his first dose. The vet threw one on the floor for my Bear and he ate it when we got home next day I put one in his food bowl but he did not eat all day that evening I google dermaxx and ran across this site and went got the pill out of the dog bowl, my dog weighs pounds, he at 1 pound of dog food in 4 days, I finally scramble some eggs on the fourth day and mixed it up he started eating again the next day same thing by the 7 day he was back to eating.

She told me I have lots of dogs take it with no problem, I said think about it, how many has died and you thought it was something else. I then sent her this site and we parted ways. Taking them with famotidine is a must. Thanks for the article. I do need to input that so far, 10 days, this has seemed to be a Godsend as it totally clears up his limp, relieves his pain, and makes him his same sweet self again. I will be asking for blood tests tomorrow thanks to you. I do have to ask, though, what do you for your dog to relieve his pain etc. So sorry for your loss and again, thanks for sharing.

Some dogs do fine on it, which is great. It sounds like yours might be one of them. I hope his numbers come back perfect. I know it might not be the choice for everyone but it worked for us. I will definitely share this will all my friends who have pets. I am so sorry for you and your family.

It was hard to read this without crying, so I can just imagine what you are feeling. Amy, I deeply empathize with your story and I am so very sorry. A year and a half ago, we lost our Corgi, Roane suddenly. And she did… mostly. But over the next few months, she still had a little less of an appetite, a tad less energy, and would sometimes go off into the other room and curl up in the corner.

Because she was happy and still pretty energetic, I put it down to her getting older she was 11, which is still young for a corgi. Then we boarded her during comic-con. The night after we picked her up, Tony was rubbing her tummy and felt something strange. I felt it too and knew immediately that it was very very wrong. The next day we took her in and found out she had a large tumor and would most likely pass away within days. Finally, during the SCBWI conference, it was clear that she was suffering too greatly and we had to take her in to the emergency clinic and put her to sleep.

It was the hardest thing I have ever done. Roane was the center of our household and Tony and I and our blind dog, Whistler slumped into depression. Like you I wished so many things. But at the end of it all, I can only trust that Roane knew how much we loved her. Knew that we tried our best to keep her safe and healthy. It still weighs on me, but I have to know, as you need to as well, that you did your best for your friend, and that Holly knows that. And you are still doing your best for her by writing about it and warning others.

So thank you and I am so sorry for your loss. So much love to you and your family. My gorgeous, sweet greyhound six yrs old has been on Deramaxx since middle of June. What began as a slight limp turned out to be osteosarcoma bone cancer. Dorrie was given an IV infusion and started on Deramaxx.

Her tumor has grown now and she limps constantly. I am treating her pain with Tramadol 50 mg. She pants heavily when in pain. Her infusions are every weeks but are palliative and not a cure. She is still eating well and goes on her four block walk two times a day.

Today when I went to get her Deramaxx refilled I was given another nsaid as they were out of Deramaxx. She was given a drug called Rimadyl. It recently has been shown to hold scientific worth in the areas of liver protection and general anti-oxidant activity, as well as being classified as an adaptogen reducing the effects of stress on the body.

It is also used as a Testosterone Booster , although no direct evidence exists in humans for this. It has also been demonstrated to hinder reproductive capacity. Many studies not using an ethanol-extract, suggesting the active ingredients may be fat-soluble in nature. Probably one of the only testosterone boosting compounds whether it works or not that hinders spermatogenesis, possibly related to the ursolic acid content.

This leads to an estimated human dose of:. These are estimated human dosages based on animal research, and it is unsure if they are the optimal doses for humans. The Human Effect Matrix looks at human studies it excludes animal and in vitro studies to tell you what effects holy basil has on your body, and how strong these effects are.

Holy Basil, also known as Tulsi, is an Ayurvetic plant traditionally used for general health and a long life. Its herbal name is Ocimum Tenuiflorum , although Ocimum Sanctum is commonly seen as a synonym; these two terms as well as Holy Basil and Tulsi are all interchangeable in regards to supplementation. Eugenol, [3] which tends to be seen as the active ingredient [4]. Bioflavonols such as Apigenin and lutein [5]. In otherwise healthy subjects given ocimum sanctum twice daily mg each time after meals over the course of two months, supplementation appeared to reduce symptoms of generalized anxiety disorders as assessed by the BPRS.

One human trial noted that after 4 weeks consumption of mg ethanolic extract of Tulsi leaves, that participants experienced an increase in some cytokines associated with the immune system; interferon-y IFN-y , interleukin-4 IL-4 , as well as T-helper cells and NK-cells. When cells were isolated from subjects and pro-inflammatory chemicals were added LPS, phytohaemagglutinin the immune cells of the Tulsi group were more effective in mounting an adaptive immune response via IFN-y and T-helper cells and NK-cells.

These immunomodulatory effects may be secondary to the flavonoid content of Tulsi. The only noted effects of Holy Basil on testosterone levels are from a rabbit study ingesting 2g of Holy Basil per day. A possible explanation being a possible androgenic analogue in Holy Basil which increases testosterone sufficiently enough to repress luteinizing and follicle-stimulating hormones significantly.

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