Your input about the person's symptoms, typical thinking and everyday abilities will be important for a proper diagnosis and for finding the underlying cause. If you notice signs and symptoms of delirium in a person in a hospital or nursing home, report your concerns to the nursing staff or doctor rather than assuming that those problems have been observed.
Older people recovering in the hospital or living in a long-term care facility are particularly at risk of delirium. Delirium occurs when the normal sending and receiving of signals in the brain become impaired.
This impairment is most likely caused by a combination of factors that make the brain vulnerable and trigger a malfunction in brain activity. Delirium may have a single cause or more than one cause, such as a combination of a medical condition and drug toxicity. Sometimes no cause can be identified. Any condition that results in a hospital stay, especially in intensive care or after surgery, increases the risk of delirium, as does being a resident in a nursing home. Delirium is more common in older adults.
Delirium may last only a few hours or as long as several weeks or months. If issues contributing to delirium are addressed, the recovery time is often shorter. The degree of recovery depends to some extent on the health and mental status before the onset of delirium. People with dementia, for example, may experience a significant overall decline in memory and thinking skills. People in better health are more likely to fully recover. People with other serious, chronic or terminal illnesses may not regain the levels of thinking skills or functioning that they had before the onset of delirium.
Delirium in seriously ill people is also more likely to lead to:. The most successful approach to preventing delirium is to target risk factors that might trigger an episode. Hospital environments present a special challenge — frequent room changes, invasive procedures, loud noises, poor lighting, and lack of natural light and sleep can worsen confusion. Evidence indicates that certain strategies — promoting good sleep habits, helping the person remain calm and well-oriented, and helping prevent medical problems or other complications — can help prevent or reduce the severity of delirium.
Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission.
This content does not have an English version. This content does not have an Arabic version. Overview Delirium is a serious disturbance in mental abilities that results in confused thinking and reduced awareness of the environment. Request an Appointment at Mayo Clinic. American Psychiatric Association; Accessed May 1, Merck Manual Professional Version. Francis J Jr, et al. There is evidence from the history, physical examination, or laboratory findings that the disturbance is a direct physiological consequence of another medical condition, substance intoxication or withdrawal i.
Back to top Diagnostic Features Delirium is a potentially life-threatening disorder characterized by an acute, fluctuating change in mental status, with inattention, disorganized thinking, and altered levels of consciousness. The individual with Delirium may be hyperactive, hypoactive, or a mixture of both.
Treatment should immediately attempt to treat the physical cause of the Delirium. Other causes of Delirium are: Effective Therapies Outcome depends on the physical cause of the Delirium. Antipsychotic medication [1] , high-dose lorazepam, or electroconvulsive therapy ECT is effective for the Delirium caused by Bipolar I Disorder [2] [3]. Neuroleptic malignant syndrome caused by antipsychotic medication and serotonin syndrome caused by SSRI antidepressant medication can both cause Delirium.
Many other medications and medical disorders can cause Delirium. Antipsychotic medication can cause neuroleptic malignant syndrome which can cause a delirium. Serotonin toxicity caused by medications that increase brain serotonin can cause serotonin syndrome which can cause a delirium. I often say that when you can measure what you are speaking about and express it in numbers you know something about it; but when you cannot measure it, when you cannot express it in numbers, your knowledge is of a meagre and unsatisfactory kind: If you read nothing else about research, you owe it to yourself to watch this short video - it is excellent!
Economist in grim battle against deceptive scholarship List of Predatory Journals and Publishers The power of asking "what if? The active placebo effect bears witness to this ancient wisdom. Watch Benny Hinn and his wife's performances. The Daily Show Criteria For High Quality Research Studies It is troubling that a recent study found that two-thirds of important psychological research studies couldn't be replicated. High quality research must meet the following criteria: Was the trial randomized?
Was the randomization procedure described and was it appropriate?
The best research design is to have research subjects randomly assigned to an experimental or control group. It is essential that confounding factors be controlled for by having a control group or comparator condition no intervention, placebo, care as usual etc. Do the research subjects represent a normal cross-section of the population being studied? Many psychological research studies using university students are flawed because their subjects are not representative of the normal population since they are all W.
White, Educated, Intelligent, Rich, and living in a Democracy. Was the treatment allocation concealed?
It is essential that the research subjects are kept "blind" as to whether they are in the experimental or control group in order to control for any placebo effects. Were blind outcome assessments conducted? In a double blind study, neither the research subjects nor the outcome assessors know if the research subject is in the experimental or control group. This controls for both the placebo effect and assessor bias.
Were groups similar at baseline on prognostic indicators? The experimental and control groups must be shown to be comparable at the beginning of the study.
Were there factors, that weren't controlled for, that could have seriously distorted the study's results? For example, research studies on the effectiveness of mindfulness cognitive therapy in preventing depressive relapse forgot to control for whether the research subjects were also simultaneously receiving antidepressant medication or other psychological treatments for depression. Was the research study protocal strictly followed? The research subjects must be shown to be compliant e.
Was a statistical power calculation described? The study should discuss its statistical power analysis; that is whether the study size is large enough to statistically detect a difference between the experimental and control group should it occur and usually this requires at least 50 research subjects in the study.
Are the results both statistically significant and clinically significant? Many medical research findings are statistically significant with a p-value clinically significant because the difference between the experimental and control groups is too small to be clinically relevant. Statistically, the best way to test for clinical significance is to test for effect size i. When the outcome of interest is a dichotomous variable, the commonly used measures of effect size include the odds ratio OR , the relative risk RR , and the risk difference RD.
When the outcome is a continuous variable, then the effect size is commonly represented as either the mean difference MD or the standardised mean difference SMD. The MD is the difference in the means of the treatment group and the control group, while the SMD is the MD divided by the standard deviation SD , derived from either or both of the groups.
With Standard Mean Difference, the general rule of thumb is that a score of 0 to 0. It is a convention that a SMD of 0. The statistical summary should report what percentage of the total variance of the dependent variable e. In clinical studies, the study should report the number needed to treat for an additional beneficial outcome NNTB , and the number needed to treat for an additional harmful outcome NNTH. This is defined as the number of patients that need to be treated for one of them to benefit compared with a control in a clinical trial.
It is defined as the inverse of the absolute risk reduction. Statistically, the NNTB depends on which control group is used for comparison - e. This is defined as the number of patients that need to be treated for one of them to be harmed compared with a control in a clinical trial. It is defined as the inverse of the absolute increase in risk of harm. Does the researcher accept full responsibility for the study's statistical analysis?
Completeness of follow-up data: Was the number of withdrawals or dropouts in each group mentioned, and were reasons given for these withdrawals or dropouts? The intervention effect should persist over an adequate length of time. Handling of missing data: Was the statistical analysis conducted on the intention-to-treat sample? There must be use of intention-to-treat analysis as opposed to a completers-only analysis.