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Virus paper reignites prion spat

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Dowager Faux Spat Leg Warmers

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We'll publish them on our site once we've reviewed them. Item s unavailable for purchase. Please review your cart. This is an extremely complex problem, he says. Meanwhile, Bruce Chesebro, chief of the Laboratory of Persistent Viral Diseases in Montana, is concerned that the infectivity of Sotos prion solutions didnt increase proportionally with their concentration.

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Soto says this was unique to the prion strain used for those experiments, and that subsequent, unpublished, work with other prions has shown that virulence does increase with concentration. For some researchers, these are mere details, and they clearly wish that Manuelidis and her arguments would just go away. Two refused to speak to Nature, because they did not want to play any role in publicizing her work. Charles Weissmann of Scripps Florida in Jupiter says the evidence in favour of prions is incontrovertible. Although Manuelidis claims in her paper that virus-like particles from infected cells can infect other cells in culture, Weissmann says the findings are meaningless until she can purify her particles and show that they can cause disease and that they are free of the prion protein something he does not expect to happen.

Manuelidis believes that her criticism of prions has made it harder for her to publish in top journals. Its not very politically correct if you dont believe in prions, she says.

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It means that you wont get any grant money. Although many disagree with her, several prion researchers say that Manuelidiss scepticism keeps the field on its toes. To me the prion issue is settled, but its good to have this type of person, says Soto. This issue is so important that you have to be very rigorous. Science ,