Bébé Chéri 4 : La fuite (French Edition)

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Compared with the traditional hybridoma method, antibody phage display library has distinct advantages on selecting novel monoclonal antibodies and even the fully humanized antibody. Furthermore, the antibodies from phage library have following advantages. As we known, peptides are biological molecules, consisting of short sequences of amino acids, so peptides are easy to be synthesized, show low toxicity and high efficiency. Most importantly, if targeting receptors or molecules that are specially expressed on cancer cells would significantly enhance cancer therapeutic effect and reduce cancer-related mortality as well.

Thus phage display technology on screening target peptides for developing cancer drugs absolutely can offer new opportunities for the treatment of many tumor diseases. Humanized antibodies are antibodies from non-human species whose protein sequences have been modified to increase their similarity to antibody variants produced naturally in human beings. As for affinity maturation, which is the process to increase their affinity for a particular antigen via their B cells during the course of an immune response.

With repeated processes of somatic hypermutation for B-cell receptors and subsequent clonal selection to the same antigen, a host will produce antibodies of successively greater affinities. Antibody humanization has played a fundamental role in the remarkable progress of antibodies as therapeutic reagents.

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As we known, since the advent of hybridoma technology, most monoclonal antibodies derive from rodent, such as mouse, rat, rabbit, hamster, etc. But most rodent antibodies have been shown a limited use as therapeutic agents because of a short serum half-life as well as they can not trigger human effector functions. On the other hand, in some cases, the affinity of a certain antibody deriving from phage library may not be high enough for used as therapeutic agents, then affinity maturation is urgently required to preserve the epitope specificity and functional activity of the antibody as well as boost potency to the desired level.

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Classification of Phage Display Systems

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Could I get a free sample? How can I get a discount? After sending your press release to the aforementioned email address we will revise it if necessary and send it back to you via email for you to comment on as soon as possible. In order to interest the Finnish media, the press release should be written in Finnish. If you do not speak Finnish, we suggest that you discuss the matter with your supervisor and try to find someone at your department to help you with the draft.

However, should you find this difficult, please do not hesitate to contact us with your English version. The faculties provide us with the information concerning the dissertations and occasionally, for instance, the possible changes made to the name of your dissertation have not been registered there. The press release text The press release should include the following information:. Begin the press release with the most important result of your research and describe where the results can be applied to in practice — these are the main issues that reporters are interested in.

You can tell about the implementation and the methods of your research etc.

Background information You should also add your education and working history in the press release, preferably presented coherently and concisely in the manner of a complete press release:. Finally, give your contact information: Publication information Attach the publication information to the press release in the following manner: Abstract Send us also the English abstract and title of your dissertation.

Press release photo We are committed to providing the media with photos of the doctoral candidates if requested. Thus, we need a colour photo of you. You can send us a photo, a file large enough for print use dpi. Some medias prefer horizontal pictures eg. You can make an appointment by calling in advance tel. The photographer delivers the photo to the University Communication the following day.

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In the case of media interest prepare to be available and ready for interviews before the public examination of your dissertation. Always ask to see and revise the texts about your dissertation before their publication.

You also have the right to ask for the possible factual errors to be corrected. Remember the autonomy of science — you are the only person who has the right to correct or ask to revise a text written about your research. Good luck with the public examination of your dissertation! The progression and formalities of the public examination of the dissertation. Men should wear either a tailcoat with a black waistcoat or a dark suit; women should wear a black, long-sleeved dress with a small neckline without a hat. All can also wear the ceremonial gown of the University. The doctoral candidate chooses the style of clothing after talking to the Custos.

The use of ceremonial gowns is agreed upon with the janitors, tel. In the beginning of the public examination the doctoral candidate arrives into the hall first, then the Custos and then the Opponent. The audience remains standing up. During the entry and exit the Custos and the Opponent hold their Doctor's hats, if they have one, in their left hand so that the lyre is facing forward. When all are seated, the Custos introduces the doctoral candidate, the title of the dissertation, as well as the Opponent.

Then the Custos declares the public examination of the dissertation open by saying "As the Custos appointed by the faculty I declare this public examination opened.

Traditionally lectio praecursoria has dealt with the issues of the doctoral thesis, but it is not merely a lecture about the thesis. The presentation must be started with the words "Mr. Opponent, Ladies and Gentlemen". During the public examination a detailed and extensive discussion of misprints is to be avoided.

Instead the doctoral candidate can prepare for the Opponent a typed list of errors, which the Opponent can attach to the statement given to the faculty and which can be also copied for the audience. The examination should be high-level conversation between two experts of the field, about the interesting themes of the doctoral thesis. Enlightened laymen should also be able to follow the conversation and it should give them things to consider.

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As a public occasion, public examinations are visible illustrations of the university life. After the lectio praecursoria, the doctoral candidate will, still standing, ask the Opponent to present the critical comments. The request is done by saying: After the statement both the doctoral candidate and the Opponent sit down. In the beginning of the actual public examination the Opponent focuses first on the methodological and general questions.

The general examination is followed by a detailed examination. The Opponent makes a concluding statement after the detailed examination. The doctoral candidate listens to the statement standing up. The doctoral candidate turns to face the audience and solicits those people present so called extra opponents who might have some critical comments to step forward and ask for an address from the custos. Soliciting is done by saying:

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